Thomas DiRaimondo,Xi Jin,Cornelius Kloeck,Chaitan Khosla
申请号：
US14126629
公开号：
US20140322278A1
申请日:
2012.06.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2)； which methods can include inhibiting the activation of TG2 associated with enteric inflammatory disorders, which disorders may include celiac disease, irritable bowel syndrome, Crohn's Disease, dermatitis herpetiformis, and the like. In other embodiments of the invention, methods are provided for reducing undesirable paracellular transport in enteric tissues, in particular the paracellular transport of molecules greater than about 500 mw, e.g. peptides, including without limitation immunogenic gluten peptides.
