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Chemical receptor of cll-1 and its usage (cll-1)
专利权人:
AMGEN, INC.;KITE PHARMA, INC.
发明人:
申请号:
ARP170100821
公开号:
AR108066A1
申请日:
2017.03.31
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Carriers, components and methods for treatment and / or detection using cll-1 antigen molecules and manipulated immune cells. Claim 1: a chemical antigen receptor, comprising an antigen binding molecule specifically bound to cll-1, wherein the antigen binding molecule comprises at least (a) a variable heavy chain CDR1 containing an amino acid sequence selected from the SEC group. Ibid., Nos. 17, 51, 73 and 95, (b) a variable heavy chain CDR2, including a series of amino acids selected from the SEC group. Ibid., Nos. 18, 52, 74 and 96.(c) A variable heavy chain CDR3 comprising a series of amino acids selected from the SEC group. Ibid., Nos. 19, 53, 75 and 97, (d) a variable light chain CDR1, including a series of amino acids selected from the SEC group. Ibid., Nos. 22, 56, 78 and 100, (E) a variable light chain CDR2, including a series of amino acids selected from the SEC group. Ibid., Nos. 23, 57, 79 and 101, (f) a variable light chain CDR3, including a series of amino acids selected from the SEC group. Ibid., No. 24, 58.Page: 1 Claim 58: an isolated polynucleotide, which encrypts a chemical antigen receptor or T cell receptor,This includes an antigen binding molecule that specifically binds to cll-1, wherein the antigen binding molecule includes a variable light chain CDR3 containing a series of amino acids selected from the SEC group. Ibid., Nos. 24, 58, 80 and 102.Vectores, composiciones y métodos de tratamiento y/o detección utilizando las moléculas de unión al antígeno de CLL-1 y las células inmunes manipuladas. Reivindicación 1: Un receptor de antígeno quimérico que comprende una molécula de unión a antígeno que se une específicamente a CLL-1, en donde la molécula de unión a antígeno comprende al menos uno de: a) una CDR1 de cadena pesada variable que comprende una secuencia de aminoácidos seleccionada del grupo que consiste en las SEC. ID. Nº 17, 51, 73 y 95, b) una CDR2 de cadena pesada variable que comprende una secuencia de aminoácidos seleccionada del gru
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