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Benzo [b] thiophene compounds as agonists of Sting
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
ARP170102751
公开号:
AR109788A1
申请日:
2017.10.02
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
That may be useful as Inducing the production of Type I interferons, specifically as active agents of Sting.They also provide procedures for the synthesis and use of compounds of the present.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof, in which r¹ is selected from the group consisting of H, halogen, or⁶, N (r⁶) ₂, sr⁶, alkyl c₁₋₆,Haloalquilo c₁₋₆, or⁶ c₁₋₆ replaced by alkyl, alkyl substituted by alkyl c₁₋₆ sr⁶, c₁₋₆ replaced by N (r⁶) ₂, haloalquilo c₁₋₆ replaced by or⁶, haloalquilo c₁₋₆ replaced by sr⁶,And haloalquilo c₁₋₆ replaced by N (r⁶) ₂; R² is selected from the group consisting of H, halogen, CN, or⁶, N (r⁶ ₂, coor⁶), C (o) n (r⁶) ₂, sr⁶, so₂r⁶, alkyl c₁₋₆, haloalquilo c₁₋₆, alquenilo c₂₋₆,Haloalquenilo c₂₋₆, alquinilo c₂₋₆, haloalquinilo c₂₋₆, cycloalkyl c₃₋₆, and a Heterocyclic Ring of 3 to 6 members that includes 1 to 2 Ring Member selected from the group consisting, orS, N, and N (r⁶), in which the alkyl c₁₋₆, haloalquilo c₁₋₆, alquenilo c₂₋₆, haloalquenilo c₂₋₆, alquinilo c₂₋₆, haloalquinilo c₂₋₆, cycloalkyl c₃₋₆,The Heterocyclic ring and groups of 3 to 6 members are optionally substituted by one or more substituents independently selected from the group consisting or⁶, CN, N (r⁶) ₂, and sr⁶,And in these c₃₋₆ and Heterocyclic cycloalkyl Ring 3 to 6 members are each replaced optionally additionally by a Group Member is c₁₋₃ alkyl and haloalquilOr c₁₋₃; r³ is selected from the group consisting of H, halogen, CN, or⁶, N (r⁶ ₂, coor⁶), C (o) n (r⁶) ₂, sr⁶, so₂r⁶, alkyl c₁₋₆, haloalquilo c₁₋₆, alquenilo c₂₋₆, haloalquenilo c₂₋₆, alquinilo c₂₋₆,Haloalquinilo c₂₋₆, cycloalkyl c₃₋₆, and a Heterocyclic Ring of 3 to 6 members that includes 1 to 2 Ring Member selected from the group consisting of o, S, N, and N (r⁶)In such c₁₋₆ alkyl, haloalquilo c₁₋₆, alquenilo c₂₋₆, haloalquenilo c₂₋₆, alquinilo c₂₋₆, haloalquinilo c₂₋₆, cycloalkyl c₃₋₆,The Heterocyclic ring and groups of 3 to 6 members are optionally substituted by one or mo
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