Heath M. GUAY;Margot O'TOOLE;Sadhana JAIN;Maya ARAI;Yulia VUGMEYSTER;Deborah A. YOUNG;Davinder GILL;Karissa K. ADKINS;Amy Arlene WEAVER;Laird BLOOM
发明人:
Laird BLOOM,Davinder GILL,Yulia VUGMEYSTER,Deborah A. YOUNG,Margot O'TOOLE,Heath M. GUAY,Karissa K. ADKINS,Amy Arlene WEAVER,Sadhana JAIN,Maya ARAI,Margot OTOOLE
申请号：
US13470500
公开号：
US20120276102A1
申请日:
2012.05.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
