PROCÉDÉ DE RECHERCHE ET DE DÉPISTAGE D'UNE CIBLE D'AGENT ANTICANCÉREUX À L'AIDE D'UN MODÈLE ANIMAL NON HUMAIN DANS LEQUEL A ÉTÉ TRANSPLANTÉE UNE LIGNÉE DE CELLULES CANCÉREUSES ÉTABLIE SUR NOG
Pharmalogicals Research Pte. Ltd.;Chugai Seiyaku Kabushiki Kaisha;Ciea International Inc.
发明人:
申请号：
EP10839531.0
公开号：
EP2517555A1
申请日:
2010.12.24
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
An objective of the present invention is to provide non-human animal models of cancer pathology, which mimic the hierarchical organization, cancer progression process, or biological property of human cancer tissues, and uses thereof. To achieve the objective described above, first, the present inventors transplanted cells of NOG-established cancer lines into NOG mice and morphologically observed the resulting tissue organization. As a result, the non-human animal models were demonstrated to exhibit pathologies (the hierarchical organization, cancer progression process, or biological properties of the cancer cells) similar to that of human cancer. Specifically, the present inventors succeeded in preparing non-human animal models exhibiting pathologies more similar to a human cancer, and cell culture systems using NOG-established cancer cell lines where the in vitro cell morphology is more similar to that of human cancer.
