Zhi Hu,Jian-hua Mao,Wen-Lin Kuo,Ge Huang,Joe W. Gray
申请号：
US14281888
公开号：
US20150080410A1
申请日:
2014.05.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Developed here is a mitotic network comprising a signature of up to 54 genes, and including also sub-sets of genes within the signature, which can identify members by requiring higher correlation values for a signature gene. The present mitotic network provides for methods for prognosis and diagnosis of various cancers. The mitotic network is conserved across cancers exhibiting aberrant mitotic activity and several genes in the network act as therapeutic targets. Development of other inhibitors of mitosis can apply expression values of the genes in the mitotic network from patient tissue to select patients during clinical validation of the new drugs.
