President and Fellows of Harvard College;YEDA RESEARCH AND DEVELOPMENT CO., LTD.
发明人:
申请号：
EP14188800.8
公开号：
EP2848627A2
申请日:
1999.07.23
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array； wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides or peptides to the mammal.
