An agent for use in medicine, which agent comprises a plurality of ligandscovalently co-linked so as to form a complex with a plurality of C-reactiveprotein (CRP) molecules in the presence thereof, wherein (i) at least two ofthe ligands are the same or different and are capable of being bound by ligandbinding sites present on the CRP molecules； or (ii) at least one of theligands is capable of being bound by a ligand binding site present on a CRPmolecule, and at least one other of the ligands is capable of being bound by aligand binding site present on a serum amyloid P component (SAP) molecule.
