Systems and methods are provided for determining patient adherence to amedication protocol by evaluating healthcare transactions. An e-prescriptiontransaction canbe received from a prescriber and evaluated to determine if the patient is toreceive adherenceanalysis. If so, the e-prescription data can be stored and the e-prescriptioncan be forwardedto a pharmacy. A healthcare claim transaction for a medication can be receivedfrom thepharmacy and forwarded on for adjudication. If approved, the claim transactiondata can beevaluated to determine if it matches any stored e-prescription data records.Upon identifyinga match, a prescription fill status notification can be generated andtransmitted to theprescriber computer associated with the prescriber of the medication in the e-prescription. Ifthe healthcare claim transaction is for a refill or a maintenance medication,a patientadherence level can be calculated and included in the prescription fill statusnotification.
