A method for guiding a therapy delivery device to a sympathetic nerve chain target of a subject includes: (a) selecting a sympathetic nerve chain target (b) using ultrasound imaging to obtain an ultrasound image of anatomical structures relevant to the sympathetic nerve chain target (c) determining an implantation pathway based on the ultrasound image, the implantation pathway defining a trajectory that avoids the relevant anatomical structures and extends between an insertion point on the skin of the subject and a bony spinous target (d) inserting an introducer into the insertion point, the introducer including a bevel located at a distal end thereof (e) navigating the introducer through the implantation pathway until the distal tip is positioned adjacent or proximate to the bony spinous target and (f) advancing the therapy delivery device through the introducer to the sympathetic nerve chain target. Steps (d)-(f) are performed using real-time ultrasound imaging.
