PROBLEM TO BE SOLVED: To provide a method for inhibiting or improving brain atrophy, and a therapeutic method or a preventive method for diseases relating to brain atrophy.SOLUTION: A brain atrophy prevention agent comprises a phospholipid containing a highly unsaturated fatty acid as a constituent fatty acid, as an active ingredient. The highly unsaturated fatty acid is preferably an n-3 highly unsaturated fatty acid.【課題】脳萎縮を抑制又は改善する方法、および脳萎縮に関連する疾患の治療方法又は予防方法の提供。【解決手段】高度不飽和脂肪酸を構成脂肪酸として含むリン脂質を有効成分として含有する脳萎縮抑制剤。【選択図】なし