A drug-eluting sheath (DES) comprises an inner elastic layer, an outer elastic layer, and at least a therapeutic agent layer said therapeutic agent layer is sandwiched partly between said inner layer and said outer layer. Said outer layer has several splittable structures on its outer surface. The DES is put on a slightly flattened catheter balloon, which guarantees both the DES and the balloon are elastically combined. The balloon carried with the DES is advanced to the treatment site of the tubular organ, and then inflated, wherein the inflating splits the outer elastic layer to expose the therapeutic agent layer to the treatment site. After treatment, the balloon is deflated, withdrawn, cleaned, and replaced with a new DES for repetitively reusing the balloon to the same patient.
