PARENTERAL PHARMACEUTICAL FORMULATION IN SUSPENSION, HAVING SUSTAINED RELEASE, IN LOW AND ULTRALOW DOSAGE, IN HORMONAL THERAPY IN THE CLIMACTERIC SYNDROME
TECHSPHERE, S.A. DE C.V.;테크스피어 에스.에이. 드 씨.브이.; S.A. DE C.V.;TECHSPHERE
发明人:
ANGELES URIBE JUAN,엔젤레스 우리베 주앙,SAVOIR VILBOEUF JOHN CLAUDE,사부아르 빌뵈프 존 클라우드
申请号：
KR1020127015583
公开号：
KR1020120114269A
申请日:
2010.12.14
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
Parenteral pharmaceutical formulation or composition, in suspension, having sustained release, containing suspended particles of estradiol and progesterone for hormonal replacement in female mammals in low and ultralow dosage； the formulation consists of an injectable suspension comprising particles of estradiol, particles of progesterone, a surfactant agent, an isosmotic agent, a thickening agent, and one or more preservation agents, wherein the estradiol is in particles having a size between 1 and 100 microns and the progesterone is in particles having a size between 1 and 100 microns, for application thereof in parenteral, intramuscular, subcutaneous or intradermal pharmaceutical form.본 발명은 저 및 극-저 용량으로 여성 포유류의 호르몬 대체용 에스트라디올 및 프로게스테론 입자를 포함하며, 계면 활성제, 등삼투압제, 점도 증가제 및 하나 이상의 보존제에 의해 형성된 주사 가능한 서방형의 현탁액인 비경구용 약학적 제제에 관한 발명이다.
