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A PROCESS FOR PREPARING A STABLE DRUG DELIVERY SYSTEM
专利权人:
发明人:
PANDA HIMANSHU SEKHAR,SRIVASTAVA ROHIT,BAHADUR DHIRENDRA
申请号:
IN2093/MUM/2008
公开号:
IN272410B
申请日:
2008.09.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The invention relates to a process for preparing a stable delivery system for an anionic statin drug, the process comprising contacting the drug, under stirring in an inert atmosphere, with aqueous solution of at least one divalent metal ion selected from the group consisting of Mg2+,Zn2+,Fe2+, Ca2+,Ni2+,Mn2+ or Co2+ and at least one trivalent metal ion selected from the group consisting of Al3+, Fe3+, Ga3+ or Cr3+ at a pH in the range of 7.5 to 9.5, allowing the metal ions to precipitate to form a layered double hydroxide with the drug intercalated therein, molar ratio of the divalent metal ion to the trivalent metal ion being in the range of 2 to 4. The invention also relates to the stable delivery system prepared by the process and the compositions and dosage forms containing the delivery system.
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