The present invention relates to bicyclo-substituted pyrazolon azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definition of substituents in formula (I) are the same as the description.本發明涉及通式(I)所示的雙環取代吡唑酮偶氮類衍生物或其藥學上可以接受的鹽、水合物或溶劑化物,其製備方法及含有該衍生物的醫藥組合物、以及作為治療劑特別是作為血小板生成素(TPO)類似物和作為血小板生成素受體激動劑的用途,其中通式(I)中的各取代基的定義與說明書中的定義相同。
