Shahnawaz Imam,Maria Alfonso-Jaume,Juan Carlos Jaume
申请号：
US16530452
公开号：
US20200037586A1
申请日:
2019.08.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A mouse model that develops type 1 diabetes spontaneously and used thereof are described. In some embodiments, the mouse model expresses a combination of HLA-DQ8 and GAD65 in a C57BL/6-BTBR congenic background, where the GAD65 is expressed under the rat insulin promoter.
