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LONG-ACTING POLYMERIC DELIVERY SYSTEMS
专利权人:
Heron Therapeutics; Inc.
发明人:
Thomas B. Ottoboni,Lee Ann Lynn Girotti
申请号:
US16107965
公开号:
US20180353608A1
申请日:
2018.08.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).
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