TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
发明人:
Joab CHAPMAN,Efrat SHAVIT-STEIN
申请号：
US15309195
公开号：
US20170072014A1
申请日:
2015.05.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed to a peptide conjugate comprising an alpha-amino protecting moiety, a peptide comprising the amino acid sequence at least 3 amino-acid long derived from the C′-terminus of PAR-1, or an active variant thereof and a protease-disabling moiety. The present invention is further directed to pharmaceutical compositions comprising the peptide conjugate and use thereof for treating diseases and disorder associated with excessive PAR-1 activity.
