Brian D. Lawrence;Alexander D. D'Addio;Phuong Grace Dang;Gul Balwani
发明人:
Phuong Grace Dang,Brian D. Lawrence,Gul Balwani,Alexander D. D'Addio,Alexander D. DAddio
申请号：
US13284836
公开号：
US20120083479A1
申请日:
2011.10.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.
