Charles RICHARDSON;Joel HAYNES;Bryan STEADMAN;Robert F. BARGATZE
发明人:
Charles RICHARDSON,Robert F. BARGATZE,Joel HAYNES,Bryan STEADMAN
申请号：
US14341375
公开号：
US20150023995A1
申请日:
2014.07.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
