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STABILIZED WATER COMPOSITIONS OF NEUROMUSCULAR BLOCKERS
专利权人:
Б. БРАУН МЕЛЬЗУНГЕН АГ (DE)
发明人:
ХИЛЬ БЕХАР Хуан (ES),ТИМОНЕДА РАМИА Кристина (ES)
申请号:
RU2015115430
公开号:
RU2015115430A
申请日:
2013.09.19
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An aqueous composition comprising (i) a neuromuscular blocker, which is a derivative of Quaternary ammonium; and (ii) an excipient selected from a polyoxy acid of the following formula: HO — CH— [CH (OH)] —COOH, where n is an integer from 1 to 8, the intramolecular lactone of said polyoxy acid, or a mixture thereof. 2. The aqueous composition according to claim 1, wherein the neuromuscular blocker, a quaternary ammonium derivative, is a compound of the following formula: wherein R and R are independently selected from tertiary amines and quaternary ammonium groups, preferably R and R are independently selected from cyclic tertiary amines and cyclic quaternary ammonium groups, where optionally additionally contains one or more heteroatoms selected from nitrogen, oxygen or sulfur, more preferably R and R are substituents of one of the following formulas: or e m is an integer from 1 to 5, X is CH, NR, NNRR, O or S (where R and R are independently H or C-C1-6alkyl, preferably H or Me), and R is C-C1-6alkyl or C-Salkenyl ; preferably m is 1 or 2, X is CH, NR, NNRR or O (where R and R are independently H or C-C1-6 alkyl) and R is methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, vinyl, allyl or butenyl; R and R are independently selected from hydroxyl or, where R is C-C1-6alkyl, provided that at least one of R or R is 3. The aqueous composition of claim 1 or 2, wherein the neuromuscular blocker, a quaternary ammonium derivative, is a rocuronium salt and the excipient is selected from D-gluconic acid, an intramolecular lactone of D-gluconic acid, preferably D-glucono-delta-lactone, or their mixtures. 4.1. Водная композиция, содержащая(i) нейромышечный блокатор, представляющий собой производное четвертичного аммония; и(ii) эксципиент, выбранный из полиоксикислоты следующей формулы: НО-СН-[СН(ОН)]-СООН, где n равен целому числу от 1 до 8, внутримолекулярного лактона указанной полиоксикислоты или их смеси.2. Водная композиция по п. 1, где нейром
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