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РЕКОМБИНАНТНЫЙ ЛЕКТИН ОМЕЛЫ БЕЛОЙ И ЕГО ПРИМЕНЕНИЕ В КАЧЕСТВЕ АДЬЮВАНТА
专利权人:
ЦИТАВИС БИОФАРМА ГМБХ (DE)
发明人:
ВИТТОН Клаус (DE),ЛЕНТЦЕН Ханс (DE)
申请号:
RU2014102348/10
公开号:
RU2014102348A
申请日:
2012.06.27
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Vaccines comprising one or more antigen and at least one adjuvant, selected from the group consisting of recombinant mistletoe lectin that include the amino acid sequence SEQ ID No. 1 and / or SEQ ID 4.2. The medicament or composition containing one or more antigen and at least one adjuvant one adjuvant, selected from the group consisting of recombinant mistletoe lectin that include the amino acid sequence SEQ ID No. 1-12, or portions thereof, and fragments, or combination thereof, for use as a vaccine, wherein the adjuvant is present in a concentration of from 5 to 600 ng / ml, in particular from 250 to 450 ng / ml, 350 ng / ml, or from 5 to 600 ng / patient, in particular from 250 to 450 ng / patient 350 ng / patsient.3. The medicament or vaccine according to any one of the preceding claims, provided that they are administered subcutaneously or vnutrimyshechno.4. A medicament according to claim. 2, wherein the polypeptide is a recombinant mistletoe lectin is the A chain of the mistletoe lectin, a selected group of amino acid sequences SEQ ID No. 1-3 or parts thereof and comprising fragments or their kombinatsiyu.5. A medicament according to claim. 2, wherein the polypeptide is a recombinant mistletoe lectin is the B chain of the mistletoe lectin, a selected group of amino acid sequences SEQ ID No. 4-12, or comprising a part thereof, and fragments thereof, or their kombinatsiyu.6. The medicament or vaccine according to any one of claims. 1 or 2, characterized in that the vaccine also comprises a pharmaceutically acceptable carrier or pharmaceutically acceptable solvent, in some cases - auxiliaries and dobavki.7. The medicament or complex1. Вакцины, содержащие один антиген или более и, по меньшей мере, один адьювант, отобранный из группы рекомбинантных лектинов омелы белой, включающих в себя аминокислотные последовательности SEQ ID No. 1 и/или SEQ ID 4.2. Лекарственное средство или композиция, содержащие один антиген или более и, по меньшей мере, один адьювант од
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