The present invention provides the materials and methods related to marking the injection site on a patients skin. Specifically, the present invention provides the materials and methods for applying a medical marking tattoo containing at least one injecting targeting site, injecting a medical substance into the area of the injection target site, and marking the injecting targeting site using a tattoo activation element. The present invention also provides the materials and methods for a medical marking apparatus that can be used to perform the methods of the present invention to mark the injection site on a patients skin.