SURI, Anish,SHERIFF, Steven,SUCHARD, Suzanne,YAMNIUK, Aaron,KRYSTEK, Stanley,TAMURA, James,BRYSON, James,GRANT, Steven,DREW, Philip
申请号：
PH12013502013
公开号：
PH12013502013B1
申请日:
2013.09.27
申请国别(地区):
PH
年份:
2013
代理人:
摘要：
Antibody polypeptides that specifically bind a novel epitope of human CD40 are provided. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides are useful in the treatment of diseases involving CD40 activation, such as autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VL or VH domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA).
