LEUWER, MARTIN,O'NEILL, PAUL,BERRY, NEIL,PIDATHALA, CHANDRAKALA,ONEILL, PAUL
申请号：
CA2933401
公开号：
CA2933401A1
申请日:
2014.12.23
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to compounds of formula (I) shown below: wherein Q is as defined herein. The compounds of formula (I) act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
