Woppmann, Claudia,VORNLOCHER, Hans-Peter,Hadwiger, Philipp,JOHN, Matthias,LIMMER, Stefan
申请号：
DK10011218
公开号：
DK2336317T3
申请日:
2004.06.14
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having improved stability in cells and biological fluids, wherein said dsRNA comprises an antisense RNA strand and a sense RNA strand, wherein said antisense RNA strand has a nucleotide sequence which is substantially complementary to a target RNA, wherein (a) one of said RNA strands comprises a 1 to 2 nucleotide overhang, (b) said dsRNA has one blunt end, and (c) said dsRNA comprises at least one chemically modified nucleotide.
