Dudler, Thomas,Gombotz, Wayne R.,Parent, James Brian,Tedford, Clark E.,Kavlie, Anita,Hagmann, Urs Beat,Reiersen, Herald,Kiprijanov, Sergej
申请号：
AU2013201779
公开号：
AU2013201779A1
申请日:
2013.03.15
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013201779A120130404.pdf#####ABSTRACT The present invention relates to anti-MASP-2 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-2 dependent complement activation. In one aspect, the invention provides an isolated human monoclonal antibody, or antigen binding fragment thereof, that binds to human MASP-2, comprising:(i) a heavy chain variable region comprising CDR-HI, CDR-H2 and CDR-H3 sequences and (ii) a light chain variable region comprising CDR-LI, CDR-L2 and CDR-L3, wherein the heavy chain variable region CDR-H3 sequence comprises an amino acid sequence set with factor B in forming additional alternative pathway C3 convertase (C3bBb). The alternative pathway C3 convertase is stabilized by the binding of properdin. Properdin extends the alternative pathway C3 convertase half-life six to ten fold. Addition of C3b to the alternative pathway C3 convertase leads to the formation of the alternative pathway C5 convertase.
