The present invention is related to a Dengue virus-like particle. Said Dengue virus-like particle exhibits almost-cut pr-M junction and is particularly suitable for producing antibody that recognizes all four types of Dengue virus. The present invention also provides antibody obtained by using said virus-like particle and composition comprising the same.本發明係有關登革熱類病毒顆粒。該登革熱類病毒顆粒呈現幾乎切割的pr-M接位，且具體而言適於製成辨識所有四種登革熱病毒的抗體。本發明亦提供利用該類病毒顆粒所取得的抗體及含其之組合物。
