BELLET, MARC,BOLLI, MARTIN,IGLARZ, MARC,KOHLER, PHILIPP,SCHINDELHOLZ, IVAN,VON RAUMER, MARKUS
申请号：
CA3083327
公开号：
CA3083327A1
申请日:
2018.11.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention concerns the compound aprocitentan, {5-(4-bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-sulfamide and its use as endothelin receptor antagonist, in combination with an SGLT-2 inhibitor. The invention further relates to pharmaceutical compositions comprising aprocitentan in combination with said SGLT-2 inhibitor. The invention further relates to such pharmaceutical compositions comprising crystalline forms of aprocitentan.
