您的位置: 首页 > 农业专利 > 详情页

GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO
专利权人:
NEUROCRINE BIOSCIENCES INC
发明人:
CHEN, MI,COON, TIMOTHY, RICHARD,BEATON, GRAHAM,EWING, TODD,JIANG, WANLONG,LOWE, RICHARD,MOREE, WILLY,SMITH, NICOLE,WADE, WARREN,ZHAO, LIREN,ZHU, YUN-FEI,ROWBOTTOM, MARTIN,ASHWEEK, NEIL
申请号:
NZ58045708
公开号:
NZ580457A
申请日:
2008.04.04
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 4-{ 5-Chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-[(2-methoxy-6-methyl-phenyl)-methyl-carbamoyl]-phenoxyl-butyric acid, 3-{ 5-Chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-[(2-methoxy-6-methyl-phenyl)-methyl-carbamoyl]-phenoxy} -propionic acid, 4-{ 5-Chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-[(2-methoxy-phenyl)-m ethyl-carbamoyl]-phenoxy} -butyric acid. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating endometriosis, uterine fibroids, polycystic ovarian disease, dysmenorrhea, dyspareunia, menorrhagia, nonmenstrual pelvic pain, pelvic tenderness, induration, general disorders of the menstrual cycle, premature ovarian failure due to chemotherapy or early menopause, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrophic pituitary adenomas, adenomyosis, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, lower urinary tract symptoms, contraception or infertility.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充