六氫吡啶經取代之MnK抑制劑及其相關方法农业专利-农业学术服务平台

发明人:: ERNST, JUSTIN T.,恩斯特　贾斯汀,恩斯特　賈斯汀,SPRENGELER, PAUL A.,斯普兰格　保罗,斯普蘭格　保羅,REICH, SIEGFRIED H.,莱许　西格弗里德,萊許　西格弗里德,SPERRY, SAMUEL,斯佩里　塞缪尔,斯佩里　塞繆爾,恩斯特贾斯汀,恩斯特賈斯汀,斯普兰格保罗,斯普蘭格保羅,莱许西格弗里德,萊許西格弗里德,斯佩里塞缪尔,斯佩里塞繆爾

摘要：: The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof wherein X1, X2, R1, R2, R3 and n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula (I) compounds as well as methods for utilizing the compounds of Formula (I) and the pharmaceutically acceptable compositions of Formula (I) compounds as inhibitors of Mnk as well as therapeutics for the treatment of diseases such as cancer.本發明關於根據式(I)之化合物：或其立體異構物、互變異構物或醫藥上可接受的鹽，其中X1、X2、R1、R2、R3和n係如本文中所定義。亦描述式(I)化合物之醫藥上可接受的組成物以及利用式(I)化合物和式(I)化合物之醫藥上可接受的組成物作為Mnk之抑制劑的方法以及治療疾病諸如癌症之療法。