1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1H-PYRAZOL-5-YL)UREE COMME INHIBITEUR DE LA KINASE TRKA
ALLEN, SHELLEY,ANDREWS, STEVEN W.,BAER, BRIAN,CRANE, ZACKARY,LIU, WEIDONG,WATSON, DANIEL JOHN
申请号：
CA2949160
公开号：
CA2949160A1
申请日:
2015.05.14
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.
