Various systems and devices are provided for determining a weaning readiness for weaning a patient from a thermoregulated microenvironment. In one example, a method includes receiving a plurality of current patient parameters of a patient housed in a thermoregulated microenvironment, applying a weaning model to the plurality of current patient parameters to generate a weaning index representing a likelihood that the patient will be successfully weaned from the microenvironment if weaned at that time, the weaning model trained to correlate the current patient parameters with the likelihood based on historical data of prior patients and known outcomes for those prior patients, and outputting the weaning index for display on a display device and/or for storage in a medical record of the patient.
