Ronald Brown Miller,Stewart Thomas Leslie,Sandra Therese Antoinette Malkowska,Derek Allan Prater,Trevor John Knott,Hassan Mohammad
申请号：
US11640749
公开号：
US08506998B2
申请日:
2006.12.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.
