Progranulin (PGRN) and its derivatives for diagnosis and treatment of lysosomal storage diseases

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专利权人:

New York University

发明人:

Liu, Chuanju,Jian, Jinlong

申请号：

AU2015214358

公开号：

AU2015214358A1

申请日:

2015.02.04

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention provides composition and methods for diagnosis and treatment of lysosomal storage diseases and their diagnosis and treatment, including Gaucher' s Disease and Tay-Sachsdisease, and particularly which utilize progranulin (PGRN), or active PGRN peptides, including atsttrin. The invention also provides animal models of lysosomal storage diseases, including Gaucher' s Disease and Tay-Sachsdisease, based on or including PGRN mutations including PGRN null mutants and PGRN gene knock outs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/