An interior monitoring method, implemented by a server coupled to a plurality of sensors deployed throughout a location, includes receiving data from the plurality of sensors, wherein the plurality of sensors are configured to monitor environmental conditions and provide data based thereon which can be used to determine cleaning and effectiveness of the cleaning for the location correlating the data and determining whether the location has been cleaned based on the correlated data. The building interior monitoring systems and methods include deploying tens to hundreds to thousands of sensors per location and continually monitoring data to determine whether the location has been cleaned or whether the location has been damaged, based on the temperature and/or pressure readings. This is particularly advantageous in environments such as hospital rooms, bathrooms, restaurants, locker rooms, etc., i.e., any environment where there is a risk for the spread of disease.