DELANEY, JOHN M.,FANSLOW III, WILLIAM CHRISTIAN,KING, CHADWICK TERENCE
申请号：
PE0003982014
公开号：
PE11512014A1
申请日:
2012.09.20
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a Binding Protein Antigen CD27L comprising: a) a light chain variable Domain that has 90% identity with the Amino Acid Sequence SEQ ID number: 63, 64, 65, 66, 67, 68, 69 and 70, which comprises (i) a lcdr1 has up to three addenda deletion or substitution. It is the Amino Acid Sequence SEQ ID number: 71, 72, 73, among others.(ii) a lcdr2 has up to three additions, deletions or substitutions of the Amino Acid Sequence SEQ ID number: 79, 80, 81, among others, and (iii) a lcdr3 has up to three additions, deletions or substitutions of the Amino Acid Sequence SEQ ID number: 87, 88, 89,Among others and (b) a variable domain of heavy chain that has 90% identity with the Amino Acid Sequence SEQ ID number: 17, 18, 19, 20, 21, 22, 23 or 24, comprising (i) a hcdr1 has up to three additions, deletions or substitutions of Amino Acid Sequence SEQ ID number: 25, 26 27, among others, (ii) a hcdr2 has up to three addenda,Deletions or substitutions of the Amino Acid Sequence SEQ ID number: 33, 34, 35, among others, and (iii) a hcdr3 has up to three additions, deletions or substitutions of the Amino Acid Sequence SEQ ID number: 41, 42, 43, among others. It also relates to a Pharmaceutical composition useful in the treatment of cancerSE REFIERE A UNA PROTEINA DE UNION AL ANTIGENO CD27L QUE COMPRENDE: A) UN DOMINIO VARIABLE DE CADENA LIGERA QUE POSEE 90% DE IDENTIDAD CON LA SECUENCIA DE AMINOACIDOS SEQ ID N�: 63, 64, 65, 66, 67, 68, 69 O 70, Y QUE COMPRENDE i) UNA LCDR1 QUE POSEE HASTA TRES ADICIONES, SUPRESIONES O SUSTITUCIONES DE AMINOACIDOS DE LA SECUENCIA SEQ ID N�: 71, 72, 73, ENTRE OTROS, ii) UNA LCDR2 QUE POSEE HASTA TRES ADICIONES, SUPRESIONES O SUSTITUCIONES DE AMINOACIDOS DE LA SECUENCIA SEQ ID N�: 79, 80, 81, ENTRE OTROS, Y iii) UNA LCDR3 QUE POSEE HASTA TRES ADICIONES, SUPRESIONES O SUSTITUCIONES DE AMINOACIDOS DE LA SECUENCIA SEQ ID N�: 87, 88, 89, ENTRE OTROS Y B) UN DOMINIO VARIABLE DE CADENA PESADA QUE POSEE 90% DE IDENTIDAD CON LA SECUENCIA DE AMINOACIDOS SEQ I
