FREIMOSER-GRUNDSCHOBER ANNE,KLEIN CHRISTIAN,MOESSNER EKKEHARD,NICOLINI VALERIA G.,HOFER THOMAS U,AST OLIVER,BRUENKER PETER,HERTER SYLVIA,HOSSE RALF,UMANA PABLO
申请号：
NZ61174912
公开号：
NZ611749A
申请日:
2012.02.07
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a mutant interleukin-2 (IL-2) polypeptide, comprising three amino acid mutations that abolish or reduce affinity of the mutant IL-2 polypeptide to the high-affinity IL-2 receptor and preserve affinity of the mutant IL-2 polypeptide to the intermediate-affinity IL-2 receptor, each compared to a wild-type IL-2 polypeptide, wherein the three amino acid mutations are at positions corresponding to residue 42, 45, and 72 of human IL-2 of SEQ ID NO: 1, wherein the sequence is as defined in the specification.
