Amani S. Awaad,Asmaa Al-Rifai,Reham M. El-Meligy,Mohamed E. Zain
申请号：
US14497265
公开号：
US09192639B1
申请日:
2014.09.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The Convolvulus extract for treating peptic ulcer and Helicobacter pylori infection is an ethanolic extract from C. pilosellifolius. The extract is prepared by homogenizing Convolvulus pilosellifolius aerial plant parts to prepare a powder, percolating the powder with an organic solvent to prepare a suspension, filtering the suspension to obtain a filtrate, and obtaining the extract as a dry powder by drying the solvent under reduced pressure from the filtrate. The active ingredient in the extract is a compound that was isolated from the extract of C. pilosellifolius as a purified triterpene using silica gel column chromatography, the compound being named: 2-propoxyethyl 13-(4-ethoxy-4-oxobutyl)-6b,8a12b,14a-tetramethyl-5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14a-tetradecahydropicene-2-carboxylate. Both the extract and the isolated active ingredient exhibit anti-ulcerogenic activity, and disk diffusion tests show that various strains of H. pylori are susceptible to both the extract and the active ingredient.
