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Alkyl cellulose for use in tableting and solid preparation comprising same
专利权人:
Shin-Etsu Chemical Co.; Ltd.
发明人:
Takuya Yokosawa,Naosuke Maruyama
申请号:
US15622354
公开号:
US10058509B2
申请日:
2017.06.14
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.
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