Junbo Gong,Qi Wang,Qiuxiang Yin,Jingkang Wang,Xiaopeng Song,Baohong Hou,Liting Liao,Duanming Tan,Ziyuan Di
申请号：
US15302944
公开号：
US09815848B2
申请日:
2014.12.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.
