Floris Louis VAN DELFT,Remon VAN GEEL,Maria Antonia WIJDEVEN,Jorge Merijn Mathieu VERKADE,Ryan HEESBEEN
申请号：
US15029159
公开号：
US20160235861A1
申请日:
2014.10.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to glycoengineered antibodies and antibody-conjugates. In particular, the invention relates to an antibody conjugate, prepared from IgG antibody comprising at least two N-linked glycosylation sites on the combination of a single heavy chain and single light chain. The invention further relates to methods for the preparation of the antibody-conjugates according to the invention. In particular, the invention relates to an antibody-drug conjugate that is conjugated to different toxins, and the a process for the preparation thereof.
