The present invention provides a hemodialysis solution or concentrate thereof including creatine compound(s), the use of creatine compound(s) for preparing a dialysis solution or concentrate thereof, a method for preparing creatine-containing dialysis solutions and concentrates, and a method for treating patients with dialysis dependent renal failure with creatine compounds to provide a variety of significant health benefits and improvement of life quality parameters for dialysis patients. This is achieve by supporting and improving the physiological functions of organs and cells via creatine compounds delivery to the patients, and by protecting organs and cells of the patients from deleterious effects of a variety of endogenous or exogenous cellular stressors that are linked to the disease state or to the clinical treatment modalities. Furthermore, in peritoneal dialysis solutions creatine can be used as an osmotic agent preventing side effects caused by high glucose supplementation.
