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MÉTHODE DE TRAITEMENT DU CANCER DU SEIN POSITIF AUX RÉCEPTEURS ANDROGÈNES (AR+) AVEC MODULATEUR SÉLECTIF DES RÉCEPTEURS ANDROGÈNES (SARM)
专利权人:
GTx; Inc.
发明人:
申请号:
EP13817231.7
公开号:
EP2872482A2
申请日:
2013.03.07
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; l) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention.Cette invention concerne le traitement du cancer du sein positif aux récepteurs androgènes (AR+). L'invention concerne des méthodes permettant de : a) traiter une patiente atteinte d'un cancer du sein; b) traiter une patiente atteinte d'un cancer du sein métastatique; c) traiter une patiente atteinte d'un cancer du sein réfractaire; d) traiter une patiente atteinte d'un cancer du sein AR-positif; e) traiter une patiente atteinte d'un cancer du se
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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