MCCLAIN, JAMES B.,TAYLOR, CHARLES DOUGLAS,ZANI, BRETT G.,KIORPES, TIMOTHY CHARLES
申请号：
CA2823355
公开号：
CA2823355A1
申请日:
2011.12.29
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.
