NAZARENKO, ANNA BORISOVNA,RABINOVICH, EDUARD ZINOVIEVICH,OVCHINNIKOV, MIKHAIL VLADIMIROVICH
申请号：
EP11863081
公开号：
EP2695891A4
申请日:
2011.09.27
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The invention relates to octapeptides being octreotide derivatives and also to imaging agents based on it used to diagnose tumours, i.e. in chemistry and medicine. Octapeptide being an octreotide derivative has common formula (1): where X and Y are H, or chelating group, namely OTA, covalently bound to ± - or µ-amino groups of N end lysine. Octapeptide with formula (1) forms a chelating complex with radionuclides, e.g. in the form of gallium isotopes 68 Ga , 66 Ga, 67 Ga to obtain the imaging agent. The imaging agent is used for diagnosing tumours expressing somatostatine receptors or their metastases. 3 non-protected formulas, 1 protected formula, 8 examples, 3 tables, 1 figure
