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bisheteroaryl derivatives as modulators of protein aggregation
专利权人:
UCB BIOPHARMA SPRL
发明人:
ADRIAN HALL
申请号:
BR112019011932
公开号:
BR112019011932A2
申请日:
2018.01.23
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
The present invention relates to certain bisheteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, retarding, or inhibiting protein aggregation, and methods of treating diseases that are present. associated with protein aggregation, including neurodegenerative diseases such as parkinson's disease, alzheimer's disease, lewy's body disease, dementia parkinson's disease, frontotemporal dementia, huntington's disease, amyotrophic lateral sclerosis, and multiple system atrophy , and cancer including melanoma.a presente invenção refere-se a certos compostos de bis-heteroarila, composições farmacêuticas que os contenham, e métodos de usá-los, incluindo métodos para prevenir, reverter, retardar, ou inibir a agregação de proteína, e métodos de tratar doenças que estão associadas com a agregação de proteína, incluindo doenças neurodegenerativas tais como doença de parkinson, doença de alzheimer, doença de corpo de lewy, doença de parkinson com demência, demência fronto-temporal, doença de huntington, esclerose lateral amiotrófica, e atrofia de sistema múltiplo, e câncer incluindo melanoma.
来源网站:
中国工程科技知识中心
来源网址:
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