Hassan Pajouhesh,Mike Grimwood,Yongbao Zhu,Yanbing Ding,Richard Holland
申请号：
US13393369
公开号：
US20120220603A1
申请日:
2010.09.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds of formula (I) which are useful in ameliorating conditions characterized by unwanted sodium and/or calcium channel activity, particularly unwanted NaV 1.7, NaV 1.8, or CaV 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine linked through an amide, isoxazole or similar linker to an aryl ring are described and are shown to be useful for the treatment of pain or epilepsy. A is selected from Formulae (i) or (ii).
