Cell membrane translocation of regulated snare inhibitors, compositions therefor, and methods for treatment of disease

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专利权人:

Ira Sanders

发明人:

Ira Sanders

申请号：

US12940826

公开号：

US09504735B2

申请日:

2010.11.05

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Compositions and methods of modulating cellular function and treatment of disease in mammals comprising locally administering a regulated SNARE inhibitor and a translocating agent to the mammal. Regulated SNARE inhibitors include clostridial neurotoxins, tetanus neurotoxin and their free light chain portions and IgA protease. Translocating agents include acids, encapsulating vectors, and transduction domains.

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