GUDE Markus (CH),ГУДЕ Маркус (CH),KhUBShVERLEN Kristian (FR),ХУБШВЕРЛЕН Кристиан (FR),RJuEhDI Georg (CH),РЮЭДИ Георг (CH),SJuRIVE Zhan-Filipp (FR),СЮРИВЕ Жан-Филипп (FR),TsUMBRUNN-AKLEN Kornelija (CH),GUDE MARKUS,ГУДЕ Маркус,KHUBSHVERLEN KRISTIAN,ХУБШВЕРЛЕН Кристиан,RJUEHDI GEORG,РЮЭДИ Георг,SJURIVE ZHAN-FILIPP,СЮРИВЕ Жан-Филипп,TSUMBRUNN-AKLEN KORNELIJA,ЦУМБРУНН-АКЛЕН Корнелия
申请号：
RU2009141310/04
公开号：
RU0002506263C2
申请日:
2008.04.10
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to compound of formula I in which R1 represents halogen, methoxy group or cyano group； each of Y1 and Y2 represents CH, and one or two from U, V, W and X represent N, and each remaining one represents CH, or in case X, cam also represent CRa, or Ra represents halogen； A represents CH2CH(OH), CH2CH(NH2), CH(OH)CH(NH2) or CH(NH2)CH2, B represents CH2CH2, CH2NH or CONH, and D represents CH2, or A represents CH(OH)CH2, and B represents CH2NH, N(R2)CO or CONH, and D represents CH2, or B represents N(R2a)CH2, and D represents CH(OH), or A represents CH(OH)CH(OH), B represents CH2NH or CONH and D represents CH2, or A represents CH2CH2, and B represents CH2CH2, CH2NR3, NHCO, CONR4, CH2O, COCH2 or CH2CH2NH, and D represents CH2, or B represents CH2NH, and D represents CO, or A also represents CH2CH2, B represents NR4bCH2 and D represents CH(OH), or A represents CH=CH, B represents CH2NR5 or CONR6, and D represents CH2, or A represents C≡C, B represents CH2NH and D represents CO, or A represents COCH2, B represents CONH and D represents CH2, or A represents CH2N(R7), and B represents CH2CH2, a D represents CH2, or B represents CH2CH(OH), a D represents CH(OH), or A represents NHCH2, and B represents CH2NH, a D represents CH2, or B represents CH2NH, a D represents CO, or A represents NHCO, B represents CH(R8)NH or CH2CH2, and D represents CH2, or A represents OCH2, B represents CH=CH or CONH, and D represents CH2； R2 represents (C1-C4)alkyl； R2a represents hydrogen； R3 represents hydrogen, CO-(CH2)p-COOR3', (CH2)p-COOR3, (C2-C5)acyl or amino(C1-C4)alkyl, or also R3 represents (C1-C4)alkyl, which can be one or two times substituted with hydroxygroup, p stands for integer number from 1 to 4, and R3 represents hydrogen or (C1-C4)alkyl； R4 represents hydrogen or (C1-C4)alkyl； R4b represents hydrogen； R5 represents hydrogen or (C2-C5)acyl； R6 represents hydrogen or (C1-C4)alkyl； R7 represents hydrogen or (C1-C4)alkyl, which can be one
